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The NIH AIDS Reagent Program has been transitioned to the NIH HIV Reagent Program which is managed by American Type Culture Collection (ATCC). We want to ensure your continued use of the materials within the NIH HIV Reagent Program with minimal impact to you. The NIH HIV Reagent Program materials are provided at no cost to registered researchers (shipping charges apply).
ARP-12028, Human Immunodeficiency Virus-Type 1 (HIV-1) IIIB p24 Protein, Recombinant from Baculovirus, is a key element to construct a conical-shaped viral core. The appropriate form of the core structure is essential for virus infection. It was once believed that core uncoating occurred in the cytoplasm. However, recent findings show that intact core has been delivered to the integration site in the nucleus. A related item is ARP-13126.
Image credit: (Molpgraphfan/CC-BY-SA-4.0)
ARP-12033, a recombinant monoclonal antibody to Human Immunodeficiency Virus type 1 (HIV-1) gp120 CD4 binding site, is a broadly neutralizing antibody for HIV treatment in the Phase 2 trial. VRC01 is a potential drug to prevent HIV-1 acquisition and to treat people currently living with HIV. The efficacy and activity are evaluated in several clinical studies, including the NIAID-funded HIV Vaccine Trials Network (HVTN) and HIV Prevention Trials Network (HPTN), known as HVTN 703/HPTN 081.
Image credit: (NIAID/CC BY 2.0)
ARP-95, HIV-1 LAV-Infected 8E5 cells, is a cell line known to contain a single integrated copy of HIV provirus per cell, which directs synthesis of defective virus particles. This cell line can be used for HIV genome quantification. Click here for more information on ARP-95.
The HIV Reagent program offers a recombinant gp120 protein from human immunodeficiency virus type 1 (HIV-1) strain BaL, a glycoprotein found on the outer surface of the virus. Consisting of viral membrane spikes (3 molecules of gp120 linked together and anchored to the membrane by gp41 protein), it is essential for viral infection, as it facilitates HIV entry into the host cell. Click here for more information on ARP-4961.
Image Credit: ATCC
For information and forms regarding registration with the NIH HIV Reagent Program, click here.
After your registration application has been approved by NIAID and ATCC, you will receive a login name and password. After logging in, find the reagent you need using the search function. Select the items from the search results to see the product detail pages. After you read the product detail page description, click the "Add to cart" button to place the item into your shopping cart. The NIH HIV Reagent Program materials are provided at no cost to registered researchers (shipping charges apply). For additional information, click here.
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The NIH HIV Reagent Program acquires, authenticates, produces and distributes a variety of materials within several biosafety levels and classifications. We understand that some researchers may only choose to order non-infectious research grade reagents through the NIH HIV Reagent Program.
The Knowledge Base is an informational database assembled by our Support Specialists and Scientific Staff which provides additional knowledge about the NIH HIV Reagent Program and reagents through questions and answers.