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Quantity limit per order
for this item is 1. This item can be ordered twice a year. Orders over this
limit will be sent to NIAID for approval before shipment.
Antibody Class: IgG2a
ARP-11338 is a high-affinity
monoclonal antibody to human immunodeficiency virus 1 (HIV-1) reverse transcriptase
by a hybridoma cell line generated by the fusion of P3X63Ag8.653 myeloma cells with immunized
BALB/c mouse splenocytes. Mice were
inoculated with lysates from Escherichia coli expressing
HIV-1 reverse transcriptase as a TrpE-RT fusion protein.
Antibody reacts with HIV-1 reverse transcriptase
(RT). The epitope is mapped to amino acids 294 to 319
(PLTEEAELELAENREILKEPVHGVY). ARP-11338 reacts with p66/p51 by
Western blot and is suitable for use in ELISA and immunofluorescence assays.
Note: ARP-11338 may be stored at 4°C for short-term
storage and at -80°C for long term storage. Avoid freeze-thaw cycles as reagent
degradation may result.
Each vial of ARP-11338 contains approximately
100 µL of culture supernatant.
Please refer to the appropriate data sheet for lot-specific information.
Szilvay, A. M.,
et al. “Epitope Mapping of HIV-1 Reverse Transcriptase with Monoclonal Antibodies
that Inhibit Polymerase and RNase H Activities.”J. Acquir. Immune
Defic. Syndr. 5 (1992): 647-657. PubMed: 1377241.
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Do NOT reference NIH HIV Reagent Program or ATCC Catalog Numbers in the Material Description
fields found on the permits and/or forms.
Make sure your name and address on the permit applications and/or forms are exactly
as they appear on your NIH HIV Reagent Program registration.
Information about permits is provided as a courtesy to NIH HIV Reagent Program customers.
While we use reasonable efforts to include accurate and up-to-date information on
this page, we make no warranties or representation as to its accuracy.
For more information on the necessary compliance requirements associated with the
biological materials provided by NIH HIV Reagent Program, please select this link: Compliance Requirements.
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