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Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Antibody class: IgG1
ARP-12174 is an anti-gp120 CD4 binding site monoclonal antibody purified from HEK 293-6E cell expression system by protein A affinity chromatography.
ARP-12174 is a clonal variant of the mAb VRC01 (reagent #12033) isolated from the same donor. NIH45-46 was obtained using a YU2 trimer as opposed to a resurfaced gp120 core, which was used to isolate VRC01 and VRC03 (reagent #12032). NIH45-46 was more potent than VRC01 in TZM-bl neutralization assays. For more information, please see the reference cited below.
Note: The user should determine the optimal concentration for any application.
Each vial of ARP-12174 contains 500 µg ofpurified antibody at a concentration of 5 mg/mL in DPBS, pH7.2 containing 20% glycerol. Endotoxin content is 0.2 EU/mg.
Note: Avoid freeze-thaw cycles as reagent degradation may result.
Please refer to the attached file(s) for more information.
Please include references cited below in publications.
Diskin, R., et al. “Increasing the Potency and
Breadth of an Anti-HIV Antibody using Structure-Based Rational Design.” Science
334 (2011), 1289-1293. PubMed: 22033520.
When applying for permits and forms please:
Do NOT reference NIH HIV Reagent Program or ATCC Catalog Numbers in the Material Description
fields found on the permits and/or forms.
Make sure your name and address on the permit applications and/or forms are exactly
as they appear on your NIH HIV Reagent Program registration.
Information about permits is provided as a courtesy to NIH HIV Reagent Program customers.
While we use reasonable efforts to include accurate and up-to-date information on
this page, we make no warranties or representation as to its accuracy.
For more information on the necessary compliance requirements associated with the
biological materials provided by NIH HIV Reagent Program, please select this link: Compliance Requirements.
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